Daptomycin 103060-53-3 pou Maladi Enfektye
Pwodwi detay
| Non | Daptomicin |
| Nimewo CAS | 103060-53-3 |
| Fòmil molekilè | C72H101N17O26 |
| Pwa molekilè | 1620.67 |
| Nimewo EINECS | 600-389-2 |
| Pwen k ap fonn | 202-204 °C |
| Pwen bouyi | 2078.2±65.0 °C (Prevwa) |
| Dansite | 1.45±0.1 g/cm3 (Prevwa) |
| Flash pwen | 87℃ |
| Kondisyon depo | Sele nan sèk, Sere nan frizè, anba -20 ° C |
| Solibilite | Methanol: soluble 5mg/mL |
| Koyefisyan asidite | (pKa) 4.00±0.10 (Prevwa) |
| Fòm | poud |
| Koulè | san koulè ak jòn endispoze |
Sinonim
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornitinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamil-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Deskripsyon
Daptomycin antibyotik la se yon antibyotik lipopeptide siklik ki gen yon nouvo estrikti ki sòti nan bouyon fèmantasyon Streptomyces (S. reseosporus), ki anpeche byosentèz peptidoglikan mi selil bakteri lè li deranje transpò asid amine nan manbràn selilè a.Chanje pwopriyete manbràn sitoplasmik la ka deranje fonksyon manbràn bakteri nan plizyè fason epi rapidman touye bakteri Gram-pozitif.Anplis kapasite li pou aji sou bakteri Gram-pozitif ki pi enpòtan nan klinik, daptomycin pi enpòtan pou tansyon izole ki te montre rezistans nan methicillin, vancomycin, ak linezolid nan vitro.Li gen aktivite ki pisan, ak pwopriyete sa a gen enplikasyon klinik trè enpòtan pou pasyan ki malad grav ki enfekte.Nemoni eozinofil se yon maladi ki ra ak grav anpil ak sentòm tankou lafyèv, tous, souf kout, ak difikilte pou respire.
Efè anti-bakteri
Daptomycin gen bon aktivite bakteryostatik kont divès bakteri antibyotik ki reziste, tankou MIC = 0.06-0.5 μg / ml pou Staphylococcus aureus ki reziste methicillin (MRSA), ak methicillin ki reziste Staphylococcus aureus (MRSA).MIC = 0.0625 ~ 1μg / ml pou bakteri, MIC = 0.12 ~ 0.5μg / ml pou Staphylococcus epidermidis ki reziste oxacillin, MIC = 2.5μg / ml pou enterococcus trè rezistan nan antibyotik aminoglikozid, MIC = 2.5μg / ml pou GmrBIa / ml pou GmrBIa. nan Enterococcus se 0.5～1μg/ml, ak MIC nan Enterococcus rezistan a antibyotik glikopeptid se 1～2μg/ml.
