Daptomycin 103060-53-3 pou maladi enfeksyon
Detay Product
| Non | Daptomycin |
| Nimewo Cas | 103060-53-3 |
| Fòmil molekilè | C72H101N17O26 |
| Pwa molekilè | 1620.67 |
| Nimewo einecs | 600-389-2 |
| Pwen k ap fonn | 202-204 ° C |
| Pwen bouyi | 2078.2 ± 65.0 ° C (prevwa) |
| Densite | 1.45 ± 0.1 g/cm3 (prevwa) |
| Pwen flash | 87 ℃ |
| Kondisyon depo | Sele nan sèk, magazen nan frizè, anba -20 ° C |
| Solubility | Methanol: soluble5mg/ml |
| Koyefisyan asidite | (PKA) 4.00 ± 0.10 (prevwa) |
| Fòm | poud |
| Koulè | san koulè endispoze jòn |
Sinonim
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-] ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxod ecyl) -l-triptofil-d-asparaginil-L-α-aspartyl-l-threonylglycyl-l-ornitinil-L-α-aspartyl-D-alanyl-L-α-aspartilglisil-D-Seryl- (3R) -3-methyl-L-α- Glutamyl-α, 2-Diamino-γ-oxo-benzenebutanoicacid (13-4) lactone; daptomycine; dapcin; daptomycin,> = 99%;
Deskripsyon
Daptomycin antibyotik la se yon antibyotik lipopeptid siklik ak yon nouvo estrikti ki soti nan bouyon fèmantasyon nan streptomyces (S. reseosporus), ki anpeche biosentèz la nan miray selil bakteri peptidoglycan pa twoublan transpò a nan asid amine nan manbràn selil la. Chanje pwopriyete yo nan manbràn nan sitoplasmik ka deranje fonksyon manbràn bakteri nan plizyè fason ak rapidman touye gram-pozitif bakteri yo. Anplis de kapasite li nan aji sou pi klinikman ki enpòtan bakteri gram-pozitif, daptomycin se pi enpòtan pou tansyon izole ki te montre rezistans nan methicillin, vankomisin, ak linezolid nan vitro. Li gen aktivite ki pisan, ak pwopriyete sa a gen enplikasyon trè enpòtan nan klinik pou malad grav ki enfekte pasyan yo. Nemoni eozinofilik se yon maladi ki ra epi ki grav anpil ak sentòm ki gen ladan lafyèv, tous, souf kout, ak difikilte pou respire.
Efè anti -bakteri
Daptomycin gen bon aktivite bakteriostatik kont divès kalite bakteri antibyotik ki reziste, tankou MIC = 0.06-0.5 μg/mL pou methicillin ki reziste staphylococcus aureus (MRSA), ak methicillin ki reziste staphylococcus aureus (MRSA). MIC=0.0625～1μg/ml for bacteria, MIC=0.12～0.5μg/ml for oxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml for enterococcus highly resistant to aminoglycoside antibiotics, MIC=2.5μg/ml for GmrBIa -The MIC of Enterococcus is 0.5 ～ 1μg/ml, ak MIC a nan enterokok rezistan a antibyotik glikopeptid se 1 ～ 2μg/mL.
